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There are 10 eight-letter words containing A, C, I and 2U

ACICULUMaciculum n. (Botany, zoology) A needlelike spine or bristle, specially the seta of an annelid.
ACICULUM n. (Latin) a bristlelike part.
APICULUSapiculus n. (Mycology) The part of a spore which attaches to the sterigmata at the end of a basidium.
APICULUS n. (Latin) a sharp point at the end of a leaf.
AURICULAauricula n. (Anatomy) The external part of the ear.
auricula n. (Anatomy) A small conical pouch projecting from either atrium of the heart.
auricula n. (Palynology) A pronounced thickening at the corner of a trilete spore, beyond the end of the laesura.
CAUTIOUScautious adj. Using or exercising caution; careful; tentative.
CAUTIOUS adj. exercising prudence.
CUBICULAcubicula n. Plural of cubiculum.
CUBICULUM n. (Latin) a burial chamber.
CUTICULAcuticula n. (Zoology, botany) A tough protective covering outside the epidermis of many invertebrates and plants; cuticle.
CUTICULA n. (Latin) the outer hard covering of an insect.
GUAIACUMguaiacum n. Any of a number of species of tree of the genus Guaiacum, native to the West Indies and parts of the Americas.
guaiacum n. The wood or resin of this tree.
GUAIACUM n. a medicinal resin, also GUAIAC, GUAIOCUM.
GUAIOCUMGUAIOCUM n. a medicinal resin, also GUAIACUM, GUAIAC.
NUDICAULNUDICAUL adj. having a leafless stem, also NUDICAULOUS.
PIRARUCUpirarucu n. A fish, the arapaima (Arapaima gigas).
PIRARUCU n. (Tupi) a large South American fish, aka arapaima.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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