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There are 2 six-letter words containing 2A, I, O and P

ANOPIAanopia n. (Medicine) State or condition of sightlessness, often due to medical reasons.
ANOPIA n. a visual defect, an upward squint, also ANOOPSIA, ANOPSIA.
APORIAaporia n. (Rhetoric) An expression of deliberation with oneself regarding uncertainty or doubt as to how to proceed.
aporia n. (Philosophy, post-structuralism) An insoluble contradiction in a text’s meaning; a logical impasse suggested…
APORIA n. a professed doubt of what to say or to choose, as in 'to be or not to be'.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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