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There are 3 five-letter words containing A, 2E, M and N

AMENEamene adj. Pleasant; agreeable.
AMENE adj. pleasant, offering amenity.
ENEMAenema n. An injection of fluid into the large intestine by way of the rectum, usually for medical purposes.
enema n. The fluid so injected.
enema n. A device for administering such an injection.
MEANEmeane n. (Archaic, music) The middle voice of a three-voice polyphonic musical composition.
MEANE v. (Scots) to lament, moan, also MEIN, MENE.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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