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There are 4 twelve-letter words containing A, E, 2M and X

AXISYMMETRICaxisymmetric adj. Exhibiting symmetry around an axis; exhibiting cylindrical symmetry.
axi-symmetric adj. Alternative form of axisymmetric.
AXISYMMETRIC adj. symmetrical in respect to an axis, also AXISYMMETRICAL.
HEXAGRAMMOIDHEXAGRAMMOID n. a hexagram shape.
MYXEDEMATOUSmyxedematous adj. Relating to, or exhibiting, myxedema.
MYXEDEMATOUS adj. (US) relating to myxedema, a skin disease, also MYXOEDEMATOUS.
XERANTHEMUMSxeranthemums n. Plural of xeranthemum.
XERANTHEMUM n. any plant of the Xeranthemum genus of plants of southern Europe, belonging to the thistle family.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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