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There are 3 four-letter words containing A, C, E and N

ACNEacne n. (Pathology) A skin condition, usually of the face, that is common in adolescents. It is characterised…
acne n. A pattern of blemishes in an area of skin resulting from the skin condition.
ACNE n. a skin disease caused by inflammation of the sebaceous follicles, esp. on the face, neck, and shoulders.
ANCE-ance suff. Added to an adjective or verb to form a noun indicating a state or condition, such as result or capacity…
-ance suff. Added to a verb to form a noun indicating a process or action.
ANCE adv. (dialect) once, also YINCE.
CANEcane n. A plant with simple stems, like bamboo or sugar cane, or the stem thereof.
cane n. The stem of such a plant adapted for use as a tool.
cane n. A rod-shaped tool or device, somewhat like a cane.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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